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邓桂胜

发布日期:2019年11月26日 15:38浏览次数:


邓桂胜

性 别:男

学历:博士

职称:教授

其他:硕士生导师


汉族,博士,湖南师范大学教授,有机化学专业硕士生导师。E-mailgsdeng@hunnu.edu.cn

一、主要教育背景及研究工作经历

湖南师范大学化学化工学院(1992.07–迄今),香港科技大学生物化学系副研究员(2005.10–2008.01);香港城市大学生物及化学系博士后(2003.06–2005.06);北京大学化学院博士后(2000.10–2002.09);浙江大学化学系获博士学位(1996.09–1999.06);东北师范大学化学系获硕士学位(1989.09—1992.06);湘南学院化学系(1979.09–1982.06)。

二、研究方向

主要研究方向为有机合成、金属有机化学、元素有机化学。目前主要从事Lewis酸调控的烯醇钛试剂的区域及立体选择性反应、反应区域选择性控制开关的设计及杂环化合物的合成,有机活性中间体的合成及催化选择性反应、官能团化叶立德的合成及反应等方面的研究。

三、近年来主持及参与的研究课题

(1)国家自然科学基金面上项目《新型手性烯醇钛试剂与共轭不饱和羰基化合物的区域及立体选择性反应及其合成应用研究》(21372071),主持,已结题(2014.1-2017.12);

(2)湖南省自然科学基金面上项目《基于三向选择性切换新型4-吡喃酮、3-呋喃酮及4-吡喃酮骈吡唑合成及应用研究》(2016JJ2080),主持,在研(2016.1-2018.12);

(3)北京分子科学国家实验室开放课题基金《新型重氮官能团化杂环化合物的区域选择性合成及应用研究》,主持,已结题(2016.1-2017.12);

(4)国家自然科学基金面上项目《立体选择性金属卡宾反应》(20172002),主要参与者,已结题;

(5)湖南省教育厅科学研究项目《重氮化合物的区域和立体选择性合成反应》(03C247),主持,已结题;

(6)中国博士后基金31期《立体选择性金属卡宾反应》,主持,已结题;

(7)湖南师大博士启动基金《铟促进的C-C偶联反应及InCl3催化酯化反应在有机合成中的应用》,主持,已结题。

四、教学及指导学生情况

承担本科生《有机化学》、《有机化学实验》、《高等有机化学》、《有机合成化学》、《化学奥赛研究》及研究生《有机合成化学》等的教学。指导硕士研究生16人、38名本科生毕业论文、38名本科生中期水平实验;指导湖南省研究生创新性实验项目3项(CX2011B212(罗景)、CX2013B233(王峰)、CX2016B206(刘为顺))、国家级本科生创新实验性项目1项(2008级欧玮辉等)及校级本科生创新实验性项目2项(2011级段丽霞等、2013级张婷等)。

硕士研究生名录:

方 林(2016级)

张建芳(2016级)

涂现侠(2016级)

万银波(2017级)

唐 玲(2017级)

彭海云(2018级)

杨 琴(2018级)



毕业硕士研究生名录:

任铁刚(1999-2002)

许百华(2002-2005)

刘春玉(2003-2006)

邹敬源(2007-2010)

莫宏华(2008-2011)

孙腾飞(2009-2012)

罗 景(2010-2013)

王 峰(2012-2015)

吴承贵(2013-2016)

陆声乐(2014-2017)

陈 波(2014-2017)

刘为顺(2015-2018)

毛善检(2015-2018)



指导本科生毕业论文名录(部分):

唐志勇(2005级)

唐石云(2005级)

霍 娇(2006级)

邓云良(2006级)

汤 力(2007级)

刘 叠(2007级)

周 佳(2007级)

欧玮辉(2008级)

黄志友(2008级)

范建红(2008级)

刘 辉(2010级)

郭伟凯(2010级)

李亚月(2010级)

韦咨羽(2010级)

刘 武(2010级)

康 璐(2010级)

许江伟(2010级)

谢巧玲(2010级)

段丽霞(2011级)

何亚丽(2011级)

杨 颖(2011级)

高倩文(2012级)

周耀庭(2012级)

席少君(2012级)

沈利亭(2013级)

刘佳怡(2013级)

张英阁(2013级)

罗 俪(2014级)



五、发表的论文(已在国内外核心刊物Angew. Chem. Int. Ed.,Advanced Synthesis & Catalysis, Org. Lett.,J. Org. Chem., Biochimica et Biophysica Acta, Bioorg. Med. Chem. Lett., Tetrahedron Lett., Tetrahedron, Synlett., Bioorg. Chem., Synthesis等发表学术论文57篇,其中SCI论文47篇)。

论文代表作:

1. Guisheng Deng, Xue Tian, Zaohui Qu and Jianbo Wang*, “Lewis Acids Controlled Regioseletive 1,2 and 1,4 Reaction ofa,b-Unsaturated carbonyl Compounds with Ti (IV) Enolates Derived froma-Diazo-b-ketocarbonyl Compounds”,Angew. Chem. Int. Ed. Egl,2002,41(15), 2773–2776.

2. Guisheng Deng*, Feng Wang, Shengle Lu, and Bo Cheng, “Synthesis of Pyrano[3,2-c]pyrazol-7(1H)-one Derivatives by Tandem Cyclization of 2-Diazo-3,5-dioxo-6-ynoates (Ynones)”,Org. Lett.,2015,17(19), 4651–4653.

3.Feng Wang, Shengle Lu, Bo Chen, Yali Zhou, Ying Yang, andGuisheng Deng*, “Regioselective Reversal in the Cyclization of 2-Diazo-3,5-dioxo-6-ynoates (Ynones, Ynamide): Construction ofg-Pyrones and 3(2H)-Furanones Starting from Identical Materials”,Org. Lett.,2016,18(24), 6248−6251.

4. Guisheng Deng*, Baihua Xu and Chunyu Liu, “DMP-Mediated One-pot Oxidative Olefination of Silyl Ethers”,Tetrahedron,2005,61(24), 5818–5821.

5. Guisheng Deng*, Jing Luo, “Silver(I)-Catalyzed Reaction of Terminal Alkynes with (Diacetoxyiodo)benzene: A Convenient, Efficient and Clean Preparation ofa-Acetoxy Ketones”,Tetrahedron,2013,69(29), 5937–5944.

2018年

[57] Chenggui Wu, Shanjian Mao,Guisheng Deng*, and Yongge Qiu*, “Regioselective Addition of Ti Enolates to Conjugated Enones: NewInsights into the Mechanism Based on Experimental and DFT Investigation”,Tetrahedron,2018,74(23), 2819−2824.

[56] Weishun Liu, Lin Fang, Yinbo Wan,Guisheng Deng*, and Jianbo Wang, “Synthesis of 2-Cyclopropyl-4-pyrones and 5-Cyclopropyl-2-alkylene-3(2H)-furanones Based on Tandem Cyclization-CyclopropanationStrategy”,Tetrahedron,2018, in press.

[55] Bo Chen, Weishun Liu, Jianfang Zhang, Jiayi Liu,Guisheng Deng*, “Synthesis of 3-phosphonyl pyrano[3,2-c]pyrazol-7(1H)-one”,Chin. J. Org. Chem.2018,38(4), 975–980.

[54]陆声乐,涂现侠,刘为顺,沈利亭,毛善检,邓桂胜*, “无过渡金属催化2-重氮-3,5-二氧代-6-炔酯(炔酮,炔酰胺)的区域选择性逆转环化:重氮g-吡喃酮和重氮3(2H)-呋喃酮衍生物的合成”,有机化学2018, 38, in press. (DOI:10.6023/cjoc201712014).

2016

[53] Feng Wang, Shengle Lu, Bo Chen, Yali Zhou, Ying Yang, andGuisheng Deng*, “Regioselective Reversal in the Cyclization of 2-Diazo-3,5-dioxo-6-ynoates (Ynones, Ynamide): Construction ofg-Pyrones and 3(2H)-Furanones Starting from Identical Materials”,Organic Letters,2016,18(24), 6248−6251.

[52] Chenggui Wu, Zhenxing Liu, Zhikun Zhang, Fei Ye,Guisheng Deng, Yan Zhang and Jianbo Wang*, “Copper(I)-Catalyzed Stereoselective Synthesis of (E)-α-Alkynyl-α,β-unsaturated Esters from a Terminal Alkyne, Diazoesters and Aldehydes”,Advanced Synthesis & Catalysis,2016,358(15), 2480–2488.

[51] Chenggui Wu, Fei Ye, Guojiao Wu, Shuai Xu, Guisheng Deng*, Yan Zhang, Jianbo Wang*, “Synthesis of Allenylphosphonates through Cu(I)-Catalyzed Coupling of Terminal Alkynes with Diazophosphonates”,Synthesis2016, 48(05), 751–760.

2015

[50] Guisheng Deng*, Feng Wang, Shengle Lu, and Bo Cheng, “Synthesis of Pyrano[3,2-c]pyrazol-7(1H)-one Derivatives by Tandem Cyclization of 2-Diazo-3,5-dioxo-6-ynoates (Ynones)”,Organic Letters,2015,17(19), 4651–4653.

[49] Chenggui Wu, Fangdong Hu, Zhenxing Liu,Guisheng Deng*, Fei Ye, Yan Zhang, Jianbo Wang*, “Cu(I)-catalyzed coupling of diaryldiazomethanes with terminal alkynes: an efficient synthesis of tri-aryl-substituted allenes”,Tetrahedron,2015,71(49), 9196–9201.

[48] WANG Feng,DENG Gui-sheng*, “Ag(I) and KF-Coactivated Reaction of Alkynyltrimethylsilanes with (Diacetoxyiodo)benzene”,湖南师范大学自然科学学报, 2015,38(3), 34–39.

2013

[47] Guisheng Deng*, Jing Luo, “Silver(I)-Catalyzed Reaction of Terminal Alkynes with (Diacetoxyiodo)benzene: A Convenient, Efficient and Clean Preparation ofa-Acetoxy Ketones”,Tetrahedron,2013,69(29), 5937–5944.

[46] Xiaojun Liu, Long Wu,Guisheng Deng, Gong Chen, Nan Li, Xiusheng Chu, Ding Li*, “Comparative Studies of Acyl-CoA Dehydrogenases for Monomethyl Branched Chain Substrates in Amino Acid Metabolism”, Bioorganic Chemistry,2013,47, 1–8.

2012

[45] Guisheng Deng*, Honghua Mo, Jing Luo, Jingyuan Zou, “Highly diastereoselective Mannich-type reaction of titanium enolate derived from 2′-hydroxypropiophenone”,Canadian Journal of Chemistry,2012,90(6), 542–550.

[44] Guisheng Deng* and Honghua Mo, “Diastereoselective Addition of Chlorotitanium Enolate Derived from 2′-Hydroxypropiophenone to Aldehydes”,Synthetic Communications,2012,42(18), 2676–2688.

[43] Gui Sheng Deng*, Teng Fei Sun, “Silver(I)-mediated reaction of trimethylsilylated arylacetylenes with sulfonyl chlorides: unexpected formation of vinyl sulfones”,Chinese Chemical Letters,2012,23(10), 1115–1118.

[42]邓桂胜*,孙腾飞,周佳,“新颖的银(I)催化磺酰氯与芳香端炔的反应”,有机化学201232(10), 1872–1879.

[41]邓桂胜*,莫宏华,罗景,汤力,“无碱条件下由芳香醛肟和磺酰氯制备O-磺酰基芳香醛肟”,有机化学,2012,32(11), 2177–2180.

[40] DENG Gui-sheng*, REN Tie-gang, “Acetalization of Carbonyl Compounds with Diols Catalyzed by InCl3·4H2O”,湖南师范大学自然科学学报,2012,35(4), 35–39.

2011

[39] Long Wu, Yuqin Qiao, Jinbo Gao,Guisheng Deng, Wenhua Yu, Gong Chen, Ding Li*, “Functional characterization of rat glutaryl-CoA dehydrogenase and its comparison with straight-chain acyl-CoA dehydrogenase”,Bioorganic & Medicinal Chemistry Letters,2011,21, 6667–6673.

[38] Gui Sheng Deng*, Jing Yuan Zou, Teng Fei Sun, “Efficient and convenient preparation ofN-tosylimines catalyzed by indium trichloride”,Chinese Chemical Letters,2011,22, 511–514.

2010

[37] Guisheng Deng* and Jingyuan Zou, “The first nucleophilic substitution reaction of organoindium reagents with sulfonyl chlorides: a facile method for preparation of vinyl sulfones”,ARKIVOC,2010, (ii), 186–194.

2008

[36] Jia Zeng, Long Wu, Xiaojian Zhang, Yuandong Liu,Guisheng Deng and Ding Li*, “Oct-2-en-4-ynoyl-CoA as a Specific Inhibitor of Acyl-CoA Oxidase”,Organic Letters,2008,10(19), 4287–4290.

[35] Xiaojun Liu, Long Wu,Guisheng Deng, Nan Li, Xiusheng Chu, Fei Guo, Ding Li*, “Characterization of mitochondrial trifunctional protein and its inactivation study for medicine development”,Biochimica et Biophysica Acta-Proteins and Proteomics,2008,1784(11), 1742–1749.

2007

[34] Long Wu, Jia Zeng,Guisheng Deng, Fei Guo, Nan Li, Xiaojun Liu, Xiusheng Chu, Ding Li*, “Inactivation of Thiolase by 2-Alkynoyl-CoA via Its Intrinsic Isomerase Activity”,Organic Letters,2007,9(20), 3877–3880.

[33] Xiaojun Liu,Guisheng Deng, Xiusheng Chu, Nan Li, Long Wu and Ding Li*, “Formation of an enolate intermediate is required for the reaction catalyzed by 3-hydroxyacyl-CoA dehydrogenase”,Bioorganic & Medicinal Chemistry Letters,2007,17, 3187–3190.

2006

[32] Changqing Dong,Guisheng Deng, Jianbo Wang*, “New Approaches to Polysubstituted Pyrroles andg-Lactams Based on Nucleophilic Addition of Ti(IV) Enolates Derived froma-Diazo-b-keto Carbonyl Compounds to N-Tosylimines”,The Journal of Organic Chemistry,2006,71(15), 5560–5564.

[31] Jia Zeng,Guisheng Deng, Ding Li*, “Intrinsic enoyl-CoA isomerase activity of rat acyl-CoA oxidase I”,Biochimica et Biophysica Acta,2006,1760, 78–85.

[30] Wenhua Yu, Xiusheng Chu,Guisheng Deng, Xiaojun Liu, Gong Chen, Ding Li*, “Mutation of Lys242 allows Δ3-Δ2-enoyl-CoA isomerase to acquire enoyl-CoA hydratase activity”,Biochimica et Biophysica Acta,2006,1760, 1874–1883.

[29] Jia Zeng,Guisheng Deng, Wenhua Yu and Ding Li*, “Inactivity of Medium-Chain Acyl-CoA Dehydrogenase by Oct-4-en-2-ynoyl-CoA”,Bioorganic& Medical Chemistry Letters,2006,16, 1445–1448.

[28] Mingyi Liao, Suwei Dong,Guisheng Deng, Jianbo Wang, “Synthesis of oxygen-containing heterocyclic compounds based on the intramolecular O-H insertion and Wolff rearrangement ofa-diazo carbonyl compounds”,Tetrahedron Letters,2006,47(27), 4537–4540.

[27] Gui-Sheng Deng*, Chun-Yu Liu “One-pot Approach to the Conversion of Alcohols intoa-Haloa,b-Unsaturated Esters”,Chinese Chemical Letters,2006,17(3), 329–332.

[26] Gui-Sheng Deng*, Bai-Hua Xu, Chun-Yu Liu, “One-pot synthesis ofa,b-Unsaturated Esters from Silyl Ethers by Means of In Situ Deprotection-Oxidation-Wittig Reaction”,有机化学,2006,26(9), 1295–1299.

2005

[25] Guisheng Deng*, Baihua Xu and Jianbo Wang, “A new method for the synthesis of 2-cyclopenten-1-one-5-carboxylic ester derivatives via Rh2(OAc)4-mediated intramolecular C-H insertion reaction of 4Z-b-vinyl-a-diazob-ketoesters”,Tetrahedron,2005,61(45), 10811–10817.

[24] Guisheng Deng*, Baihua Xu and Chunyu Liu, “DMP-Mediated One-pot Oxidative Olefination of Silyl Ethers”,Tetrahedron,2005,61(24), 5818–5821.

[23] Gui-Sheng Deng, Ming-Yi Liao, Xue Tian and Jian-Bo Wang*, “Regioselective 1,2-Addition of Ti(IV)-enolate toa,b-Unsaturated Compounds”,Chinese Chemical Letters,2005,16(5), 589–592.

2004

[22] Guisheng Deng*, “An efficient one-pot synthesis of alpha-thiophenyl-alpha, beta-unsaturated carbonyl compounds from arsonium salts”,有机化学,2004,24(3), 286–288.

2003

[21] Guisheng Deng, Xue Tian and Jianbo Wang*, “A Novel Approach to Two-ring Fused Cyclopentenone”,Tetrahedron Letters,2003,44(3), 587–589.

[20] Guisheng Deng* and Tiegan Ren, “Indium trichloride Catalyses Aldol-Condensations of Aldehydes and Ketones”,Synthetic Communications,2003,33(17), 2995–3001.

[19] Guisheng Deng* and Tiegan Ren, “Efficient procedure for synthesis of diacetals from InCl3·4H2O catalyzed reaction of 2,2 bis-hydroxymethyl-1,3- propanediol with aldehydes or ketones”,J. Chem. Res.(S),2003, (1), 24–25.

[18] Zhenpei Yu, Xiaoran He,Guisheng Deng and Jianbo Wang*, “Study on the Mass Spectrometry of Diazo Compounds”,J. Inst. Anal.,2003,22, Suppl. 125.

[17] Guisheng Deng, Zhizhen Huang and Xian Huang*, “A Facile Synthesis ofa-Phenylthio-a,b-Unsaturated Esters”,Chinese Chemical Letters,2003,14(1), 3–5.

[16] Gui-sheng Deng*, “The dehydration ofa-diazo-d-hydroxy-1,3-dicarbonyl compounds”,湖南师范大学自然科学学报,2003,26(3), 51–55.

[15] 邓桂胜*,“课堂教学与研究生研究思维能力的培养”,中国高教论丛,2003,25(8), 7–9.

2002

[14] Guisheng Deng, Xue Tian, Zaohui Qu and Jianbo Wang*, “Lewis Acids Controlled Regioseletive 1,2 and 1,4 Reaction ofa,b-Unsaturated carbonyl Compounds with Ti (IV) Enolates Derived froma-Diazo-b-ketocarbonyl Compounds”,Angew. Chem. Int. Ed. Egl,2002,41(15), 2773–2776.

[13] Guisheng Deng, Nan Jiang, Zhihua Ma and Jianbo Wang*, “Rh2(OAc)4-Mediated Diazo Decomposition ofd-(N-Tosyl)amino-b-keto-a-Diazo Carbonyl Compounds: A Novel Approach to Pyrrole Derivatives ”,Synlett.,2002,11, 1913–1915.

[12] Gui-Sheng Deng, Zhi-Zhen Huang and Xian Huang*, “A facile Synthesis ofa-Phenylseleno-a,b-Unsaturated Nitriles viaa-phenylselenenyl cyano methylenetriphenyl arsorane”,Synthetic Communications,2002,32(12), 1775–1780.

[11] Guisheng Deng*, “A Novel Synthesis ofa-Thio and Seleno Arsonium Ylides via the Mixed Iodonium-Arsonium Ylides”,J. Chem. Res.(S),2002, (11), 558–559.

[10] Gui-sheng Deng*, “Studies on oxidation ofa-naphthol catalyzed by binucleus copper (II) sulfophthalocyanine in ethanol water”,湖南师范大学自然科学学报,2002,25(3), 59–63.

2001

[9] Guisheng Deng* and Tiegan Ren “InCl3×4H2O Catalyzed Aldol Condensation of Cycloalkanones with Aromatic Aldehydes”,Chinese Chemical Letters,2001,12(10), 859–860.

2000

[8] Gui-Sheng Deng, Zhi-Zhen Huang, Xiao-Chun Yu and Xian Huang*, “Direct Synthesis ofa-Acryl Methylenetriphenylarsoranes from Readily Available Arsonium Salts”,Synthetic Communications,2000,31(14), 2487–2495.

[7] Gui-Sheng Deng, Zhi-Zhen Huang and Xian Huang*, “An Improved Synthesis ofa- Phenylseleno Arsonium Ylides”,Chinese Chemical Letters,2000,11 (4), 293–294.

1999

[6] Gui-Sheng Deng, Zhi-Zhen Huang, Xiao-Chun Yu and Xian Huang*, “Synthesis ofa-Phenylthioacylmethylenetriphenylarsoranes and their Wittig-type Reactions”,J. Chem. Res. (S),1999, 144–145.

[5] Gui-Sheng Deng, Zhi-Zhen Huang and Xian Huang*, “An efficient One-pot Synthesis ofa-Phenylseleno-a,b-Unsaturated Nitriles via Arsonium Salt”,Org. Prep. Proced. Int.,1999,3 (4), 453–456.

[4] Gui-Sheng Deng, Zhi-Zhen Huang and Xian Huang*, “A convenient Synthesis ofa-Phenylseleno-a,b-Unsaturated Nitriles via Arsonium salt”,Chinese Chemical Letters,1999,10(5), 349–350.

1996

[3] Qiang Xuan,Gui-Sheng Deng, Xiao-Hua Yao, Yong-Chen Shu, Zhen-Quang Zhang*, “Oxidation ofa-naphthol catalyzed by binuclear copper sulfo-phthalocyanine. 1. Preparation ofa-naphthoquinone in ethanol”,有机化学,1996,16(1), 83–87.

[2] Qiang Xuan,Gui-Sheng Deng, Xiao-Hua Yao, Yong-Chen Shu, Zhen-Quang Zhang*, “Oxidation ofa-naphthol catalyzed by binuclear copper sulfophthalocyanine in ethanol-water”,化学试剂,1996,18(3), 138–140.

1993

[1] Guisheng Deng*, Zhenquan Zheng, “Catalytic oxidation of phenols top-quinones with bi-nuclear phthalocyanine-copper (II) sulfonic acid”,湖南师范大学自然科学学报,1993,16(3), 247–252.

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