基本信息：
朱效华，男，副教授，硕士生导师。2018年6月毕业于湖南大学获理学博士学位，师从姚守拙院士与聂舟教授，2014年7月-2015年10月在清华大学李景虹院士课题组联合培养。2019年1月加入湖南师范大学化学化工学院，从事分析化学领域的教学与研究工作。先后主持国家自然科学基金、湖南省自然科学基金。目前以通讯/第一作者身份在Sci. China Chem., Nat. Commun., Nano Lett.,ACS Nano, Anal. Chem., Chem. Commun.等国内外学术期刊发表论文60余篇，ESI高引论文3篇，连续3年入选全球前2%科学家称号。
联系方式：
邮箱：zhuxiaohua@hunnu.edu.cn
地址：湖南省长沙市岳麓区麓山路36号湖南师范大学化学化工学院北305
研究领域：
生命科学中的新分析方法
近年主持的科研项目：
1.国家自然科学基金面上项目（22274048），激活型纳米探针动态示踪肿瘤浸润自然杀伤细胞激活过程研究，54万，在研，主持。
2.国家自然科学基金青年基金项目（21904039），多通道阵列传感器构建及快速鉴别免疫细胞激活状态研究，25万，已结题，主持。
3. 湖南省自然科学基金面上项目（2023JJ30394），智能型双模态纳米探针构建及其在监测肿瘤相关免疫细胞激活过程研究，5万，在研，主持。
4. 湖南省自然科学基金青年基金项目（2020JJ5352），基于超电荷荧光蛋白的循环肿瘤细胞快速检测方法，5万，已结题，主持。
5.湖南省重大科技攻关项目（2023ZJ1120），口腔癌防治关键技术研究与应用，600万，在研，参与。
代表性论文：
1.Yuquan Xiao, Boru Peng,Xiaohua Zhu,* Ying Long, Feng Liu, Meiling Liu, Haitao Li, Youyu Zhang,* Shouzhuo Yao. Machine learning-assisted multichannel nanosensor based on core-shell carbon dot/gold nanoparticle composites for rapid and precise intraoperative oral cancer malignancy diagnosis.Sci. China Chem., 2025, 68, 5273–5283.
2.Hongli Tan, Meizi Zeng, Cong Fang,Xiaohua Zhu,* Feng Liu, Ying Long, Ruijie Deng, Peng Yin, Meiling Liu, Haitao Li,* Youyu Zhang, Shouzhuo Yao. Pattern-based rapid and robust profiling of gut microbiota and its metabolism with a single fluorescent probe.Sci. China Chem., 2025, 68, 781–788.
3.Kuicheng Zhao,Xiaohua Zhu,* Feng Liu, Jun Lu, Ying Long, Bo Zhou, Cuiyan Wu, Meiling Liu, Peng Yin, Haitao Li,* Youyu Zhang, Bo Tang.* Fingerprint profiling human gut microbiota through boronic acid-based sensor array and its application on colorectal cancer classification.Nat. Commun. 2026, doi: 10.1038/s41467-026-71350-x.
4.Xiaohua Zhu,* Jiali Chen, Junyu Liao, Meixia Wang, Ying Long,* Meiling Liu, Youyu Zhang, Hong-Hui Wang.* Functionalized multichannel fluorescence-encoded nanosystem on erythrocyte-coated nanoparticles for precise cancer subtype discrimination.Nano Lett., 2025, 25, 426-433.
5.Xiaohua Zhu, Rui Tang, Shigong Wang, Xiaoye Chen, Jiajun Hu, Chunyang Lei, Yan Huang, Honghui Wang, Zhou Nie,* Shouzhuo Yao. Protein@inorganic nanodumpling system for high-loading protein delivery with activatable fluorescence andmagnetic resonance bimodal imaging capabilities.ACS Nano, 2020, 14, 2172-2182.
6.Jiao Xiang, Ziyu Liu, Meiling Liu, Youyu Zhang,Xiaohua Zhu.* Fluorogenic peptide-modulated 2D ZnO/MnO2nanosheet heterostructure enables monitoring of tumor early response to immunotherapy.Anal.Chem., 2026, 98, 3577-3587.
7.Hu Liu, Ziming Li, Shanghan Zhou, Jiali Chen, Meiling Liu, Hong-Hui Wang, Youyu Zhang, Ruijie Deng,Xiaohua Zhu.* Fluorescent protein display on cellular mimic enables rapid and accurate identification of natural killer cell phenotypes.Chem. Commun., 2025, 61, 19293-19296.
8.Shuhang Yin, Binbin Li, Boru Peng, Yongyan Shi, Feng Chen, Qiujun Lu,Xiaohua Zhu,* Meiling Liu, Haitao Li, Youyu Zhang.* DNA tetrahedral sensors for visualizing miR-21-mediated angiogenesis.Anal.Chem., 2025, 97, 19249-19257.
9.Tianyi Zhang, Yingying Zhao, Cong Zhu, Xi Zhu,Xiaohua Zhu,* Ye Qiu, Zhou Nie, Chunyang Lei.* CRISPR/Cas12a protein switch powered label-free electrochemical biosensor for sensitive viral protease detection.Anal.Chem., 2025, 97, 8039-8047.
10.Shuhang Yin, Feng Chen, Boru Peng, Yongyan Shi, Qiujun Lu,Xiaohua Zhu,* Haitao Li, Youyu Zhang.* Visualization of cancer cell-derived exosome-induced fibroblast phenotypic transformation.Anal.Chem., 2025, 97, 7098-7106.
11.Cong Fang, Quan Deng, Kuicheng Zhao, Zile Zhou,Xiaohua Zhu,* Feng Liu, Peng Yin, Meiling Liu, Haitao Li,* Youyu Zhang, Shouzhuo Yao. Fluorescent probe for investigating the mitochondrial viscosity and hydrogen peroxide changes in cerebral ischemia/reperfusion injury.Anal.Chem., 2024, 96, 3436-3444.
12.Jie Gao,Xiaohua Zhu,* Ying Long, Meiling Liu, Haitao Li,* Youyu Zhang, Shouzhuo Yao. Boronic acid-decorated carbon dot-based semiselective multichannel sensor array for cytokine discrimination and oral cancer diagnosis.Anal.Chem., 2024, 96,1795-1802.
13.Zhihui Liu,Xiaohua Zhu,* Qiujun Lu, Meiling Liu, Haitao Li,* Youyu Zhang, Yang Liu,* Shouzhuo Yao.Recognition engineering-mediated multichannel sensor array for gut microbiota sensing.Anal.Chem., 2023, 95, 5911-5919.
14.Xiaohua Zhu, Lin Fan, Shigong Wang, Chunyang Lei*, Yan Huang, Zhou Nie*, Shouzhuo Yao. Phospholipid-tailored titanium carbide nanosheets as a novel fluorescent nanoprobe for activity assay and imaging of phospholipase D.Anal.Chem., 2018, 90, 6742-6748.
15.Xiaohua Zhu, Tingbi Zhao, Zhou Nie, Yang Liu,*Shouzhuo Yao. Non-redox modulated fluorescence strategy for sensitive and selective ascorbic acid detection with highly photoluminescent nitrogen-doped carbon nanoparticles via solid-state synthesis.Anal.Chem., 2015,87,8524-8530.
16.Ruimiao Li, Yu Zhu, Lin Gong, You Fan, Jianan Zhang, Sheng Wu, Kui Luo,Xiaohua Zhu,* Meiling Liu,* Youyu Zhang, Shouzhuo Yao. Synthesis and catalytic performance of Cu-CeO2nanoparticles and the application in Cr(VI) detection: third-year undergraduate comprehensive laboratory experiment.J.Chem.Educ.,2023,100,3945-3954.
