褚宏伟讲师，硕导

基本信息：

2022年8月博士毕业，于大连理工大学-中国科学院大连化学物理研究所联合培养，师从张玉奎院士、张丽华研究员与钟世钧教授。曾获得大连化学物理研究所-岛津一等博士研究生奖学金，获岛津（中国）资助参加第49届国际HPLC大会（日本京都）做口头报告。

2023年2月加入湖南师范大学化学化工学院从事教学与科研工作。2023年12月至今，在湖南师范大学生命科学学院从事博士后研究工作，合作导师刘少军院士。2024年获中国化学会色谱专业委员会“分离科学青年创新奖”、获湖南师范大学青年教师课堂教学竞赛“十佳教学新秀”奖、“百优教学设计”奖；入选2026年湖南师范大学课堂教学示范岗。

联系方式：

邮箱：chuhongwei@hunnu.edu.cn

地址：湖南省长沙市岳麓区麓山路36号湖南师范大学化学化工学院327

研究方向：

蛋白质组和代谢组样品前处理方法开发和应用、中药小分子分离分析与功能研究

学术兼职：

湖南省食品科学技术学会青年工作委员会第一届委员

中国分析测试协会色谱专业委员会第一届委员会委员

主持项目：

1.国家自然科学基金-青年基金项目（2024-2026）

2.湖南省自然科学基金-青年基金项目（2026-2028）

3.教育部产学合作协同育人项目（2023-2024）

4.湖南师范大学引进博士科研启动项目（2023-至今）

5.湖南师范大学课程思政示范课程建设项目（2025-2026）

主要发表论文：

(1) Chunxue Gu, Shiyi Zhou, Huimin Gan, Yu Zhao, Jiatong Liu, Ming Ma*,Hongwei Chu*, Bo Chen, A stepwise ionic liquid extraction method for plant leaf protein extraction,Analytica Chimica Acta, 2025, 1372, 344439.

(2) Huimei Zeng, Xingyao Wang, Jiyu Tang, Peina Liu, Shen Zhang,Hongwei Chu*, Bo Chen, Ming Ma*, Proteomic and metabolomic analyses reveal the antibacterial mechanism of Cannabidiol against gram-positive bacteria,Journal of Proteomics, 2025, 315, 105411.

(3)Bin Qiu, Jian Li,Hongwei Chu, Yude Wang*, Shaojun Liu*, Comparative analysis of spermatozoa of Procambarus clarkii (Girard, 1852) and Cambaroides dauricus (Pallas, 1772) (Decapoda: Astacidea: Cambaridae, Cambaroididae)，Journal of Crustacean Biology, 2026, 46(1), ruag005.

[4]Hongwei Chu, Qun Zhao, Ju Liu, Kaiguang Yang, Yanlei Wang, Jianhui Liu, Kun Zhang, Baofeng Zhao*, Hongyan He*, Yong Zheng, Shijun Zhong, Zhen Liang, Lihua Zhang*, Yukui Zhang. Ionic liquid-based extraction system for in-depth analysis of membrane protein complexes.Analytical Chemistry. 2022, 94, 758-767.

[5]Hongwei Chu, Qun Zhao*, Yichu Shan, Shen Zhang, Zhigang Sui, Xiao Li, Fei Fang, Baofeng Zhao*, Shijun Zhong, Zhen Liang, Lihua Zhang*, Yukui Zhang. All-ion monitoring-directed low abundance protein quantification reveals CALB2 as a key promoter in hepatocellular carcinoma metastasis.Analytical Chemistry. 2022, 94, 6102-6111（封面论文）.

[6]Hongwei Chu, Changqing Wu, Qun Zhao, Rui Sun, Kuo Yang, Baofeng Zhao*, Yang Liu, Zhen Liang, Shijun Zhong, Lihua Zhang*, Yukui Zhang. Quantitative proteomics identifies FOLR1 to drive sorafenib resistance via activating autophagy in hepatocellular carcinoma cells.Carcinogenesis. 2021, 42, 753-761.

[7] Qun Zhao#,Hongwei Chu#(co-first), Baofeng Zhao, Zhen Liang, Lihua Zhang*, Yukui Zhang. Advances of ionic liquids-based methods for protein analysis.TrAC Trends in Analytical Chemistry. 2018, 108, 239-246.

[8] Zixuan Wang#,Hongwei Chu#(co-first), Kaiguang Yang, Baofeng Zhao*, Zhen Liang, Lihua Zhang, Yukui Zhang. Label free quantitative proteomics analysis of the sorafenib resistance in HepG2 cells.Journal of Analysis and Testing. 2021, 6:308-317.

[9]褚宏伟，郑诗颖，赵群，赵宝锋，梁振，张丽华*，张玉奎，膜蛋白质复合物提取方法研究进展，分析测试学报, 2022, 41: 1387-1394.

[10]Hongwei Chu, Pin Sun, Jiahui Yin, Guangming Liu, Yiwei Wang, Pengyao Zhao, Yizhun Zhu, Xiaohan Yang, Tiezheng Zheng, Xuezhong Zhou*, Weilin Jin*, Changkai Sun*. Integrated network analysis reveals potentially novel molecular mechanisms and therapeutic targets of refractory epilepsies.PLoS One. 2017, 12, e0174964.

[11]Hongwei Chu, Xuezhong Zhou*, Guangming Liu, Minghui Lv, Xiaofeng Zhou, Yiwei Wang, Lin Liu, Xing Li, Pin Sun, Yizhun Zhu, Changkai Sun*. Network-based detection of disease modules and potential drug targets in intractable epilepsy. The 8th International Conference on Systems Biology (ISB). 2014,135-143.

[12]郑诗颖,褚宏伟,赵群,赵宝锋,张丽华*,张玉奎.基于离子液体的蛋白质组样品制备新方法研究进展.中国科学：化学. 2021, 51.

[13] Guangming Liu, Huixin Wang,Hongwei Chu, Jian Yu*, Xuezhong Zhou*. Functional diversity of topological modules in human protein-protein interaction networks.Scientific Reports. 2017, 7, 16199.

[14] Rui Sun, Chengyong Dong, Rui Li,Hongwei Chu, Jianhui Liu, Dingjun Hao, Lihua Zhang*, Baofeng Zhao*, Liming Wang*, Yukui Zhang. Proteomic Analysis Reveals that EPHX1 Contributes to 5-Fluorouracil Resistance in a Human Hepatocellular Carcinoma Cell Line.Proteomics Clinical Applications,2020, 14, 1900080.

[15] Changqing Wu, Chaoliu Dai, Xinyu Li, Mingju Sun,Hongwei Chu, Qiuhui Xuan, Yalei Yin, Chengnan Fang, Fan Yang, Zhonghao Jiang, Qing Lv, Keqing He, Yiying Qu, Baofeng Zhao, Ke Cai, Shuijun Zhang, Ran Sun, Guowang Xu, Lihua Zhang, Siyu Sun*, Yang Liu*. AKR1C3-dependent lipid droplet formation confers hepatocellular carcinoma cell adaptability to targeted therapy.Theranostics, 2022, 12:7681-7698.

[16] Huiming Yuan*, Zhongpeng Dai, Xiaodan Zhang, Baofeng Zhao,Hongwei Chu, Lihua Zhang*, Yukui Zhang. Fully automated sample treatment method for high throughput proteome analysis.Science China-Chemistry,2021, 64, 313-321.

授权专利：

1.张丽华，褚宏伟，赵宝锋，马宝福，王子璇，杨开广，梁振，张玉奎，FOLR1抑制剂的应用和治疗肝癌药物混合物，ZL 202010722336.4

2.张丽华，褚宏伟，赵宝锋，杨开广，梁振，张玉奎，CALB2及定量检测CALB2的试剂的应用及工具，ZL 2019 1 0079619.9

3.张丽华, 褚宏伟, 赵宝锋, 杨开广, 梁振, 张玉奎,可抑制CALB2蛋白表达的抑制剂的应用和肝癌药物,ZL 2019 1 0079616.5